aTyr Pharma (NASDAQ:LIFE) & Neurocrine Biosciences (NASDAQ:NBIX) Head-To-Head Contrast

aTyr Pharma (NASDAQ:LIFE) and Neurocrine Biosciences (NASDAQ:NBIX) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, risk, dividends, analyst recommendations, profitability, earnings and valuation.

Risk & Volatility

aTyr Pharma has a beta of 2.34, meaning that its stock price is 134% more volatile than the S&P 500. Comparatively, Neurocrine Biosciences has a beta of 1.34, meaning that its stock price is 34% more volatile than the S&P 500.

Valuation and Earnings

This table compares aTyr Pharma and Neurocrine Biosciences’ top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
aTyr Pharma N/A N/A -$34.51 million ($16.11) -0.30
Neurocrine Biosciences $451.24 million 17.34 $21.11 million $0.22 389.55

Neurocrine Biosciences has higher revenue and earnings than aTyr Pharma. aTyr Pharma is trading at a lower price-to-earnings ratio than Neurocrine Biosciences, indicating that it is currently the more affordable of the two stocks.

Analyst Recommendations

This is a summary of recent ratings and recommmendations for aTyr Pharma and Neurocrine Biosciences, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
aTyr Pharma 0 3 1 0 2.25
Neurocrine Biosciences 0 3 16 0 2.84

aTyr Pharma currently has a consensus target price of $16.57, suggesting a potential upside of 237.41%. Neurocrine Biosciences has a consensus target price of $102.84, suggesting a potential upside of 20.00%. Given aTyr Pharma’s higher possible upside, analysts plainly believe aTyr Pharma is more favorable than Neurocrine Biosciences.


This table compares aTyr Pharma and Neurocrine Biosciences’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
aTyr Pharma N/A -81.33% -51.98%
Neurocrine Biosciences -7.56% -9.14% -4.21%

Institutional & Insider Ownership

30.4% of aTyr Pharma shares are held by institutional investors. Comparatively, 95.9% of Neurocrine Biosciences shares are held by institutional investors. 27.7% of aTyr Pharma shares are held by company insiders. Comparatively, 4.3% of Neurocrine Biosciences shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.


Neurocrine Biosciences beats aTyr Pharma on 9 of the 13 factors compared between the two stocks.

aTyr Pharma Company Profile

aTyr Pharma, Inc., a biotherapeutics company, engages in the discovery and development of medicines based on novel immunological pathways in the United States. Its therapeutic candidate pipeline includes ATYR1923 candidate, a fusion protein comprising the immuno-modulatory domain of histidyl tRNA synthetase fused of a human antibody that is in Phase 1b/2a clinical trial for treating patients with interstitial lung diseases (ILDs), such as pulmonary sarcoidosis; and in Phase 1 clinical trial to treat chronic hypersensitivity pneumonitis and connective tissue disease ILD. The company has a collaboration with the University of Nebraska Medical Center for the development of neuropilin-2 receptor biology; and a research collaboration and option agreement with CSL Behring for the development of product candidates derived from up to four tRNA synthetases. The company was founded in 2005 and is headquartered in San Diego, California.

Neurocrine Biosciences Company Profile

Neurocrine Biosciences, Inc. discovers and develops pharmaceuticals for the treatment of neurological and endocrine-related diseases and disorders in the United States. The company offers INGREZZA (valbenazine), a vesicular monoamine transporter 2 inhibitor (VMAT2), which is used for the treatment of movement disorders; ORILISSA, a gonadotropin-releasing hormone (GnRH) antagonist for use in women's health. Its product candidates in clinical development include elagolix that is in Phase III clinical trial for Uterine Fibroids; opicapone, a catechol-O-methyltransferase inhibitor, which is in Phase III clinical trial that is used for in adjunct therapy and preparations of levodopa/DOPA decarboxylase inhibitors for adult patients with Parkinson's disease; and NBI-74788, which is in Phase II clinical trial for the treatment of congenital adrenal hyperplasia. The company's product candidates also comprise VMAT2 Inhibitors and which are in Phase I clinical trial for neurology/psychiatry disorders. It has collaborations and agreements with AbbVie Inc. to develop and commercialize elagolix and GnRH antagonists for women's and men's health; Mitsubishi Tanabe Pharma Corporation to develop and commercialize INGREZZA for movement disorders; and BIAL – Portela & Ca, S.A. to develop and commercialize opicapone for the treatment of human diseases and conditions, including Parkinson's disease. The company also has a research collaboration agreement with Jnana Therapeutics Inc. to discover novel small molecule therapeutics for multiple targets for central nervous system disorders; and a collaboration and license agreement with Voyager Therapeutics, Inc. for the research, development, and commercialization of VY-AADC program for Parkinson's disease and VY-FXN01 program for Friedreich's ataxia. Neurocrine Biosciences, Inc. was founded in 1992 and is headquartered in San Diego, California.

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